Allyl bromide → 2-(2-Chlorophenylthio)-6-allylphenol

HRID 1164075ノート

反応式

HRID 1164075 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[OH:15].[CH2:16](Br)[CH:17]=[CH2:18].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C(C)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:18][CH:17]=[CH2:16])[C:10]=1[OH:15]

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 205134692-(2-Chlorophenylthio)phenol

生成物 1

HCID 130666682-(2-Chlorophenylthio)-6-allylphenol収率 83.5%

試薬・触媒・溶媒 1

HCID 7909Methyl Isobutyl Ketone溶媒

実験手順

A mixture of 2-(2-chlorophenylthio)phenol (33 g), allyl bromide (25 g) and dried potassium carbonate (29 g) in methyl isobutyl ketone (200 ml) was refluxed under heating for 1.5 hours. After cooling to the ambient temperature, the reaction mixture was filtered, and the filtrate was evaporated under reduced pressure. The resultant oily residue was stirred at 230° C. for 3 hours and then distilled under reduced pressure to give oily 2-(2-chlorophenylthio)-6-allylphenol (32.2 g) bp 157°-162° C./0.7 mmHg.

後処理

  1. temperaturewas refluxed
  2. temperatureunder heating for 1.5 hours
  3. filtrationthe reaction mixture was filtered
  4. customthe filtrate was evaporated under reduced pressure
  5. distillationdistilled under reduced pressure

出典と根拠

ORDレコード
ord-e1215f4f06b9471583ca78ed7edf3cc8
出典データセット
uspto-grants-1983_01
特許番号
US04367238

反応ノート

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