Sodium borohydride → 2-Hydroxy-3-(o-tolylthio)benzyl alcohol

HRID 1164107ノート

反応式

HRID 1164107 の反応式
[BH4-].[Na+].[OH:3][C:4]1[C:11]([S:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[CH:10][CH:9]=[CH:8][C:5]=1[CH:6]=[O:7]>CO>[OH:3][C:4]1[C:11]([S:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][OH:7]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 130666712-Hydroxy-3-(o-tolylthio)benzaldehyde

生成物 1

HCID 130666702-Hydroxy-3-(o-tolylthio)benzyl alcohol収率 76.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sodium borohydride (850 mg) was added slowly to a suspension of 2-hydroxy-3-(o-tolylthio)benzaldehyde (11 g) in methanol (50 ml) at temperature below 15° C., and the mixture was stirred at the same temperature for 15 minutes and then at room temperature for 30 minutes. Methanol was distilled off from the reaction mixture under reduced pressure, and the residue was dissolved in water, acidified with conc. hydrochloric acid and extracted with ethyl acetate. The extract was washed with water, dried and evaporated under reduced pressure. The residue was crystallized with aqueous ethanol to give 2-hydroxy-3-(o-tolylthio)benzyl alcohol (8.45 g), mp. 75°-77° C.

後処理

  1. waitat room temperature for 30 minutes
  2. distillationMethanol was distilled off from the reaction mixture under reduced pressure
  3. dissolutionthe residue was dissolved in water
  4. extractionextracted with ethyl acetate
  5. washThe extract was washed with water
  6. customdried
  7. customevaporated under reduced pressure
  8. customThe residue was crystallized with aqueous ethanol

出典と根拠

ORDレコード
ord-492f5b2dd853418b84394fb01ae9b39f
出典データセット
uspto-grants-1983_01
特許番号
US04367238

反応ノート

読み込み中…