Methane → Sodium 3-methoxy-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate
反応式
[CH3:1][O:2][C:3]1[CH2:9][CH:8]2[N:5]([C:6](=[O:10])[CH2:7]2)[C:4]=1[C:11]([O:13]CC1C=CC=CC=1)=[O:12].C.C(=O)(O)[O-].[Na+:26]>[Pd].O1CCOCC1.O>[CH3:1][O:2][C:3]1[CH2:9][CH:8]2[N:5]([C:6](=[O:10])[CH2:7]2)[C:4]=1[C:11]([O-:13])=[O:12].[Na+:26]参加物
6
実験手順
A mixture of benzyl 3-methoxy-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate (50 mg) and 10% palladium on powdered charcoal (50 mg) in 1:1 dioxane-H2O (5 ml) containing sodium bicarbonate (12.5 ml) is hydrogenated at 40 psi for 30 mins. The mixture is filtered and the catalyst is washed with more water (5 ml). The combined filtrate is extracted with ethyl acetate, concentrated in vacuo to ca. 2 ml, and lyophilized to yield sodium 3-methoxy-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate.
後処理
- filtrationThe mixture is filtered
- washthe catalyst is washed with more water (5 ml)
- extractionThe combined filtrate is extracted with ethyl acetate
- concentrationconcentrated in vacuo to ca. 2 ml
出典と根拠
- ORDレコード
- ord-4213cff31b454f0eb5770d8a777320a1
- 出典データセット
- uspto-grants-1983_01
- 特許番号
- US04369187
反応ノート
読み込み中…