Dimethylformamide → 1-(Chloromethyl)-4-fluoro-2-methylbenzene
反応式
S(Cl)([Cl:3])=O.[F:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12]O)=[C:8]([CH3:14])[CH:7]=1.CN(C)C=O>CC1C=CC=CC=1>[Cl:3][CH2:12][C:9]1[CH:10]=[CH:11][C:6]([F:5])=[CH:7][C:8]=1[CH3:14]参加物
5
実験手順
To 14.3 parts of thionyl chloride is added dropwise a solution of 14 parts of 4-fluoro-2-methylbenzenemethanol and 0.9 parts of N,N-dimethylformamide in 45 parts of methylbenzene while cooling in ice-water. Then there are added 135 parts of methylbenzene and stirring is continued for 1 hour at room temperature. The reaction mixture is evaporated, yielding 17 parts (100%) of 1-(chloromethyl)-4-fluoro-2-methylbenzene as a residue.
後処理
- customThe reaction mixture is evaporated
出典と根拠
- ORDレコード
- ord-d91ea89eefb84bd78f5f2ceb30f9874d
- 出典データセット
- uspto-grants-1983_01
- 特許番号
- US04369184
反応ノート
読み込み中…