Water → HCID 53792849、化合物

HRID 1164368ノート

反応式

HRID 1164368 の反応式
[Cl:1][C:2]1[C:6]([Cl:7])=[N:5][C:4](=[C:8](Cl)Cl)[N:3]=1.[CH:11]([NH:14][CH:15]=[O:16])([CH3:13])[CH3:12].[OH2:17]>C(#N)C>[CH:15]([N:14]([CH:11]([CH3:13])[CH3:12])[C:8]([C:4]1[NH:5][C:6]([Cl:7])=[C:2]([Cl:1])[N:3]=1)=[O:17])=[O:16]

参加物

5

反応物 3

HCID 962WaterHCID 268118N-(propan-2-yl)formamideHCID 124825724,5-Dichloro-2-(dichloromethylidene)-2H-imidazole

生成物 1

HCID 53792849HCID 53792849、化合物収率 84%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
0 °C

実験手順

654 g (3 mol) of 4,5-dichloro-2-dichloromethylene-imidazole in a finely powdered form were added incrementally in the course of about one hour, to a mixture, which had been initially introduced, of 783 g (9 mol) of isopropyl-formamide, 162 g (9 mol) of water and 3 l of acetonitrile, while stirring and while cooling to about 0° C. The clear solution was then poured into about 15 kg of ice water. The white precipitate which had formed was filtered off, washed with water and dried. In this way, 630 g (84% of theory) of 4,5-dichloro-imidazole-2-carboxylic acid N-formyl-isopropylamide with a melting point of 142° C. were obtained. The same result was also achieved without the addition of water.

後処理

  1. customThe white precipitate which had formed
  2. filtrationwas filtered off
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-f6fcc053ee0e4ece85666d7f86ef761b
出典データセット
uspto-grants-1983_01
特許番号
US04369186

反応ノート

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