Ethanol → 5-amino-6-chloro-2,3-dihydro-1H-indol-2-one
反応式
C(O)C.[Cl-].[NH4+].[O:6]=[C:7]1[CH2:15][C:14]2[C:9](=[CH:10][C:11]([Cl:19])=[C:12]([N+:16]([O-])=O)[CH:13]=2)[NH:8]1>[Fe].O>[O:6]=[C:7]1[CH2:15][C:14]2[C:9](=[CH:10][C:11]([Cl:19])=[C:12]([NH2:16])[CH:13]=2)[NH:8]1参加物
6
実験手順
To a mixture of ethanol (200 ml) and water (40 ml) were added ammonium chloride (2.2 g) and iron metal (19.7 g). To the mixture was added 2-oxo-5-nitro-6-chloroindoline (12.5 g) at 60° C. After refluxing for 45 minutes, the reaction mixture was filtered under warm condition. The filter cake was washed with ethanol. The combined filtrate and washings were evaporated to dryness under reduced pressure to give 2-oxo-5-amino-6-chloroindoline (10.0 g).
後処理
- temperatureAfter refluxing for 45 minutes
- filtrationthe reaction mixture was filtered
- temperatureunder warm condition
- washThe filter cake was washed with ethanol
- customThe combined filtrate and washings were evaporated to dryness under reduced pressure
出典と根拠
- ORDレコード
- ord-4d6217ddccf543cb955d7d0b60f2f2e1
- 出典データセット
- uspto-grants-1983_01
- 特許番号
- US04370340
反応ノート
読み込み中…