Propargyl alcohol → Butane, 1-bromo-4-(2-propynyloxy)-
反応式
[CH2:1]([OH:4])[C:2]#[CH:3].[Br:5][CH2:6][CH2:7][CH2:8][CH2:9]Br.[OH-].[Na+]>O>[Br:5][CH2:6][CH2:7][CH2:8][CH2:9][O:4][CH2:1][C:2]#[CH:3]参加物
5
実験手順
A mixture of 2-propyn-1-ol (10 g), 1,4-dibromobutane (60 ml), 50% aqueous sodium hydroxide (60 ml) and TAB (2 g) was stirred vigorously overnight. Water (250 ml) was added and the mixture was extracted with ether (2×200 ml). The organic extracts were dried and concentrated to a yellow oil which was purified by FCC eluting with H→H/ER (19:1) to give the title compound as a colourless oil (19.7 g), t.l.c. (H-ER 19:1) Rf 0.37.
後処理
- extractionthe mixture was extracted with ether (2×200 ml)
- customThe organic extracts were dried
- concentrationconcentrated to a yellow oil which
- customwas purified by FCC
- washeluting with H→H/ER (19:1)
出典と根拠
- ORDレコード
- ord-a6cdcdb147434c73849d3f81192984d0
- 出典データセット
- uspto-grants-1990_03
- 特許番号
- US04908386
反応ノート
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