Water → 3(2H)-Pyridazinone, 4-chloro-2-(4-chlorophenyl)-5-((4-chlorophenyl)methoxy)-

HRID 1165426

反応式

HRID 1165426 の反応式
[Cl:1][C:2]1[C:3](=[O:16])[N:4]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[N:5]=[CH:6][C:7]=1[OH:8].[Cl:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22]Cl)=[CH:20][CH:19]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[Cl:1][C:2]1[C:3](=[O:16])[N:4]([C:9]2[CH:10]=[CH:11][C:12]([Cl:15])=[CH:13][CH:14]=2)[N:5]=[CH:6][C:7]=1[O:8][CH2:22][C:21]1[CH:24]=[CH:25][C:18]([Cl:17])=[CH:19][CH:20]=1

参加物

6

反応物 4

HCID 962WaterHCID 77231-Chloro-4-(chloromethyl)benzeneHCID 11430Potassium CarbonateHCID 546974414-Chloro-2-(4-chlorophenyl)-5-hydroxypyridazin-3(2H)-one

生成物 1

HCID 30652303(2H)-Pyridazinone, 4-chloro-2-(4-chlorophenyl)-5-((4-chlorophenyl)methoxy)-収率 59.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

In 70 ml of N,N-dimethylformamide was dissolved 7.1 g (0.028 mol) of 4-chloro-2-(4-chlorophenyl)-5-hydroxy-3(2H)-pyridazinone, and thereto were added 4.5 g of p-chlorobenzyl chloride and 5.4 g of anhydrous potassium carbonate. The resulting reaction mixture was heated under stirring on an oil bath at 120° to 130° C. for 2 hours. After allowing to cool, the reaction mixture was poured into 500 ml of water. The solid thus precipitated was taken out by filtration, washed with water, dried and then recrystallized from an ethyl acetate-benzene mixture to give 6.3 g of the intended compound.

後処理

  1. customThe resulting reaction mixture
  2. temperaturewas heated
  3. temperatureto cool
  4. customThe solid thus precipitated
  5. filtrationwas taken out by filtration
  6. washwashed with water
  7. customdried
  8. customrecrystallized from an ethyl acetate-benzene mixture

出典と根拠

ORDレコード
ord-d6219f38236f43bf825b5b80f8353636
出典データセット
uspto-grants-1990_03
特許番号
US04910201

関連ノート

読み込み中…