Hydrochloric Acid → N-(4-Hydroxyphenyl)-N-(6-hydroxy-2-naphthalenyl)acetamide

HRID 1165500

反応式

HRID 1165500 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[CH:15]=[C:14]([OH:19])[CH:13]=[CH:12]3)=[CH:4][CH:3]=1.CN(C)C1C=CC=CC=1.[C:29](Cl)(=[O:31])[CH3:30].Cl>C(Cl)Cl.C1COCC1>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([OH:19])[CH:15]=3)[CH:10]=2)[C:29](=[O:31])[CH3:30])=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 949N,N-DimethylanilineHCID 6367Acetyl chlorideHCID 144992086-[(4-Hydroxyphenyl)amino]-2-naphthalenol

生成物 1

HCID 14499220N-(4-Hydroxyphenyl)-N-(6-hydroxy-2-naphthalenyl)acetamide収率 10%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 830 mg (3.30 mmol of 6-[(4-hydroxyphenyl)amino]-2-naphthalenol (prepared as described in Example 3) and 840 ul (6.60 mmol, 2 eq.) of dimethylaniline in 15 ml of dry CH2Cl2 and 5 ml of dry THF was stirred at 0° C., then 415 ul (5.80 mmol, Mallinckrodt) of acetyl chloride was added dropwise. After 50 minutes, 1N aqueous HCl was added and this was extracted with EtOAc. The organic layers were washed with 1N aqueous HCl, dried (MgSO4) and concentrated in vacuo. The aqueous layers were extracted with hot EtOAc and the organic layers were combined, dried (MgSO4) and concentrated in vacuo. Purification of all the organic phases was accomplished via flash chromatography (1:2, 1:1 EtOAc/petroleum ether) and recrystallization (aqueous MeOH) afforded 97 mg (10%) of title compound as pale orange crystals: m.p. 255° C.

後処理

  1. extractionthis was extracted with EtOAc
  2. washThe organic layers were washed with 1N aqueous HCl
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. extractionThe aqueous layers were extracted with hot EtOAc
  6. dry with materialdried (MgSO4)
  7. concentrationconcentrated in vacuo
  8. customPurification of all the organic phases
  9. customwas accomplished via flash chromatography (1:2, 1:1 EtOAc/petroleum ether) and recrystallization (aqueous MeOH)

出典と根拠

ORDレコード
ord-ccb1ae8c91c64a8f969898117ab28328
出典データセット
uspto-grants-1990_03
特許番号
US04910208

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