Water → N,N'-Dibenzyl-3-aminopyrrolidine

1,000 g (5.34 mols) of 1-benzyl-Δ3 -pyrroline-2,5-dione are dissolved in 2.5 l of tetrahydrofuran, and 572 g (5.34 mols) of benzylamine are added with stirring at 10° to 20° C. The mixture is left to stand for 24 hours at room temperature, after which 360 g are removed from the resulting solution (3,848 g of total weight) and added to a solution of 38 g (1 mol) of lithium aluminum hydride in 380 ml of absolute dehydrated tetrahydrofuran. The mixture is refluxed for 20 hours, 500 ml of tetrahydrofuran, 38 g of water and 120 ml of tetrahydrofuran, 38 g of 10% strength potassium hydroxide solution and 114 g of water are then sucessively added to the mixture. The salts are filtered off with suction, washed with tetrahydrofuran, the filtrate is concentrated, and the residue is distilled.

1. waitThe mixture is left
2. customafter which 360 g are removed from the resulting solution (3,848 g of total weight)
3. temperatureThe mixture is refluxed for 20 hours
4. filtrationThe salts are filtered off with suction
5. washwashed with tetrahydrofuran
6. concentrationthe filtrate is concentrated
7. distillationthe residue is distilled

ORDレコード

ord-88a4f23619b44c5baad87a92b773ac16

出典データセット

uspto-grants-1990_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04910319