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Water → N,N'-Dibenzyl-3-aminopyrrolidine

HRID 1165569
ノート
印刷プレビュー

反応式

HRID 1165569 の反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[K+]>O1CCCC1>[CH2:1]([N:8]1[CH2:4][CH2:3][CH:2]([NH:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:1]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 962Water2 回HCID 7504BenzylamineHCID 14797Potassium HydroxideHCID 21226445Aluminium lithium hydride

生成物 1

HCID 14098325N,N'-Dibenzyl-3-aminopyrrolidine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒4 回

実験手順

1,000 g (5.34 mols) of 1-benzyl-Δ3 -pyrroline-2,5-dione are dissolved in 2.5 l of tetrahydrofuran, and 572 g (5.34 mols) of benzylamine are added with stirring at 10° to 20° C. The mixture is left to stand for 24 hours at room temperature, after which 360 g are removed from the resulting solution (3,848 g of total weight) and added to a solution of 38 g (1 mol) of lithium aluminum hydride in 380 ml of absolute dehydrated tetrahydrofuran. The mixture is refluxed for 20 hours, 500 ml of tetrahydrofuran, 38 g of water and 120 ml of tetrahydrofuran, 38 g of 10% strength potassium hydroxide solution and 114 g of water are then sucessively added to the mixture. The salts are filtered off with suction, washed with tetrahydrofuran, the filtrate is concentrated, and the residue is distilled.

後処理

  1. waitThe mixture is left
  2. customafter which 360 g are removed from the resulting solution (3,848 g of total weight)
  3. temperatureThe mixture is refluxed for 20 hours
  4. filtrationThe salts are filtered off with suction
  5. washwashed with tetrahydrofuran
  6. concentrationthe filtrate is concentrated
  7. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-88a4f23619b44c5baad87a92b773ac16
出典データセット
uspto-grants-1990_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04910319

反応ノート

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