3'-Fluoro-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid → 4-(3-Fluoro-4-hydroxyphenyl)benzoic acid

HRID 1165730

反応式

HRID 1165730 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:18])=[O:17])=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[O:8]C>Br.O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:18])=[O:17])=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[OH:8]

参加物

4

反応物 1

HCID 12031663'-Fluoro-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid

生成物 1

HCID 8361394-(3-Fluoro-4-hydroxyphenyl)benzoic acid収率 95.1%

試薬・触媒・溶媒 2

HCID 260Hydrogen Bromide溶媒HCID 312751,4-Dioxane溶媒

実験手順

Subsequently, 6.8 g of 3'-fluoro-4'-methoxybiphenyl-4-carboxylic acid was heated under reflux for 14 hours in 150 ml of 48% hydrobromic acid and 80 ml of dioxane. The volatile components were removed by evaporator, and the residue was washed several times with water to give 6.10 g (yield 95%) of the desired 3'-fluoro-4'-hydroxybiphenyl-4-carboxylic acid.

後処理

  1. customThe volatile components were removed by evaporator
  2. washthe residue was washed several times with water

出典と根拠

ORDレコード
ord-a8047560a01440b7b48dccd7b80fcc11
出典データセット
uspto-grants-1990_03
特許番号
US04911862

関連ノート

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