HCID 69915989、化合物 → HCID 73990358、化合物
反応式
[N:1]1([C:6]2[N:11]=[CH:10][C:9]([CH:12]=[CH:13][CH2:14][OH:15])=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1>CC(C)=O.O=[Mn]=O>[N:1]1([C:6]2[N:11]=[CH:10][C:9]([CH:12]=[CH:13][CH:14]=[O:15])=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1参加物
4
実験手順
A mixture of the compound from step C (185 mg, 0.92 mmol) and MnO2 (1.60 g, 18.40 mmol) in acetone (15 mL) was heated to reflux for 1 h. The cooled reaction mixture was filtered through Celite and the filtrate was concentrated. Purification by chromatography (SiO2, 2:1 hexane/ethyl acetate) yielded 78 mg (43%) of the title compound. MS 200 (M+H)+.
後処理
- temperaturewas heated
- temperatureto reflux for 1 h
- customThe cooled reaction mixture
- filtrationwas filtered through Celite
- concentrationthe filtrate was concentrated
- customPurification by chromatography (SiO2, 2:1 hexane/ethyl acetate)
出典と根拠
- ORDレコード
- ord-3d6062b708ce43ba92e6375e571fad32
- 出典データセット
- uspto-grants-2003_09
- 特許番号
- US06613747B2
反応ノート
読み込み中…