Acetic Acid → HCID 22997643、化合物
反応式
C([O:3][C:4](=[O:14])[C:5]([C:7]1[S:8][C:9]([Br:13])=[C:10]([Br:12])[CH:11]=1)=[O:6])C.[OH-].[Na+].C(O)(=O)C>O>[Br:12][C:10]1[CH:11]=[C:7]([C:5](=[O:6])[C:4]([OH:14])=[O:3])[S:8][C:9]=1[Br:13]参加物
5
実験手順
(4,5-Dibromothiophen-2-yl)-oxo-acetic acid ethyl ester (1.00 g, 2.92 mmol) was stirred in a mixture of 5 ml water and 1 N NaOH (3.65 ml, 3.65 mmol) at room temperature for 2 hours. The reaction was then poured into 2 N acetic acid, and extracted into 100 ml ethyl acetate. The ethyl acetate layer was dried over Na2SO4 and concentrated under vacuum to provide (4,5-dibromothiophen-2-yl)-oxo-acetic acid (788 mg, 86%). MS (M−H)−: 312.73; 1H NMR (300 MHz, DMSO-d6) δ7.98 (s).
後処理
- extractionextracted into 100 ml ethyl acetate
- dry with materialThe ethyl acetate layer was dried over Na2SO4
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-7a0f327b02d84f43ace9afb683340c0d
- 出典データセット
- uspto-grants-2003_09
- 特許番号
- US06613786B2
反応ノート
読み込み中…