2,6-Dichloro-4-nitroanisole → 3,5-Dichloro-2-methoxyaniline

HRID 1166230ノート

反応式

HRID 1166230 の反応式
[N+:1]([C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([Cl:11])[C:5]=1[O:12][CH3:13])([O-])=O>[Pt]>[NH2:1][C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([Cl:11])[C:5]=1[O:12][CH3:13]

参加物

3

反応物 1

HCID 1698622,6-Dichloro-4-nitroanisole

生成物 1

HCID 112177473,5-Dichloro-2-methoxyaniline収率 95.5%

試薬・触媒・溶媒 1

HCID 23939Platinum触媒

実験手順

2-Amino-4,6-dichloroanisole was prepared by same method as described in Step 2 of Preparation 2c except using 2-nitro-4,6-dichloroanisole (13.32 g) and 10%Pt(S)/C (1.33 g). Workup gave crude 2-amino-4,6-dichloroanisole (11 g, 95%) which was used in the next step without purification. 1H NMR (300 MHz, CDCl3) δ6.73 (d, J=2.4 Hz, 1 H), 6.62 (d, J=2.4 Hz, 1 H), 3.82 (s, 3 H).

後処理

  1. custom2-Amino-4,6-dichloroanisole was prepared by same method

出典と根拠

ORDレコード
ord-2ef161a605444e929cf327adb37597dc
出典データセット
uspto-grants-2003_09
特許番号
US06613786B2

反応ノート

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