Dimethylamine, hydrochloride → 7-Methoxy-4-(dimethylaminomethyl)coumarin

反応式

Cl.[CH3:2][NH:3][CH3:4].Br[CH2:6][C:7]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=2)[O:10][C:9](=[O:19])[CH:8]=1.C(=O)([O-])[O-].[K+].[K+]>ClCCl>[CH3:18][O:17][C:13]1[CH:12]=[C:11]2[C:16]([C:7]([CH2:6][N:3]([CH3:4])[CH3:2])=[CH:8][C:9](=[O:19])[O:10]2)=[CH:15][CH:14]=1

参加物

実験手順

A mixture of dimethylamine hydrochloride (0.18 g), 4-bromomethyl-7-methoxycoumarin (0.30 g), potassium carbonate (0.5 g) and dichloromethane (10 ml) was stirred at room temperature for 2 days. The solid was filtered off and the filtrate concentrated. The residue was purified by chromatography on silica gel (eluent 5% methanol in dichloromethane), then crystallised from methanol to give the title compound as a white solid (0.145 g).