Chlorosulfonic acid → 2,5-Dichloro-4-methylbenzene-1-sulfonyl chloride
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH3:9].[Cl:10][S:11](O)(=[O:13])=[O:12]>>[Cl:8][C:5]1[CH:4]=[C:3]([CH3:9])[C:2]([Cl:1])=[CH:7][C:6]=1[S:11]([Cl:10])(=[O:13])=[O:12]参加物
3
反応条件
- 温度
- 0 °C
実験手順
A dry flask under argon was charged with chlorosulfonic acid (30 mL) and cooled to 0° C. 2,5-Dichlorotoluene (10 g, 62.1 mmol) was then added dropwise, and once the addition was complete, the reaction was heated to 60° C. and stirred for 30 min. After cooling to room temperature, the reaction mixture was poured slowly onto ice. The aqueous mixture was extracted twice with methylene chloride, and the organics were dried and concentrated to provide 2,5-dichloro-4-methylbenzenesulfonyl chloride (14.14 g, 88%) as a white solid.
後処理
- additiononce the addition
- temperaturethe reaction was heated to 60° C.
- temperatureAfter cooling to room temperature
- additionthe reaction mixture was poured slowly onto ice
- extractionThe aqueous mixture was extracted twice with methylene chloride
- customthe organics were dried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-4aa8bc8e7f39416b9f73f8c00afc4573
- 出典データセット
- uspto-grants-2003_09
- 特許番号
- US06617357B2
反応ノート
読み込み中…