Morpholine → 2-Methoxy-5-morpholin-4-ylmethyl-benzonitrile
反応式
Cl[CH2:2][C:3]1[CH:4]=[CH:5][C:6]([O:11][CH3:12])=[C:7]([CH:10]=1)[C:8]#[N:9].[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>O1CCCC1>[CH3:12][O:11][C:6]1[CH:5]=[CH:4][C:3]([CH2:2][N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:10][C:7]=1[C:8]#[N:9]参加物
4
実験手順
To a solution of 5-chloromethyl-2-methoxy-benzonitrile (246 mg, 1.354 mmol, example 29) in tetrahydrofuran (10 mL) at room temperature was added morpholine (1.193 mL, 13.54 mmol). The reaction mixture was heated at reflux for 4 h. The reaction was concentrated in vacuo (with heating) to remove morpholine and tetrahydrofuran to afford 2-methoxy-5-morpholin-4-ylmethyl-benzonitrile as a yellow oil (311.2 mg, 99%). The crude product was used without further purification.
後処理
- temperatureThe reaction mixture was heated
- temperatureat reflux for 4 h
- concentrationThe reaction was concentrated in vacuo (with heating)
- customto remove morpholine and tetrahydrofuran
出典と根拠
- ORDレコード
- ord-6bebd5ab91ac4184938f0debdedbeb45
- 出典データセット
- uspto-grants-2003_09
- 特許番号
- US06617346B1
反応ノート
読み込み中…