3-Fluoro-4-(3-cyano-1-pyrrolyl)nitrobenzene → 5-Amino-2-(3-cyano-1-pyrrolyl)fluorobenzene

HRID 1167465ノート

反応式

HRID 1167465 の反応式
[F:1][C:2]1[CH:3]=[C:4]([N+:15]([O-])=O)[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[CH:9]1>CO.[Pd]>[NH2:15][C:4]1[CH:5]=[CH:6][C:7]([N:8]2[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[CH:9]2)=[C:2]([F:1])[CH:3]=1

参加物

4

反応物 1

HCID 229960033-Fluoro-4-(3-cyano-1-pyrrolyl)nitrobenzene

生成物 1

HCID 229961405-Amino-2-(3-cyano-1-pyrrolyl)fluorobenzene

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

3-Fluoro-4-(3-cyano-1-pyrrolyl)nitrobenzene (5.3 g, 22.9 mmnol) was dissolved in hot MeOH (250 ml) and palladium catalyst (10% on charcoal, 700 mg) added under a nitrogen atmosphere. The mixture was cooled and hydrogenated at atmospheric pressure for 3.5 hours. After filtration through celite, the solution was evaporated to dryness to give title product in sufficent purity for the next stage (4.6 g).

後処理

  1. temperatureThe mixture was cooled
  2. filtrationAfter filtration through celite
  3. customthe solution was evaporated to dryness

出典と根拠

ORDレコード
ord-312b9797beda4aba96ca2a5a0f066241
出典データセット
uspto-grants-2003_09
特許番号
US06617339B1

反応ノート

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