p-Toluenesulfonic acid → 1,2-Difluoro-4-(prop-1-en-2-yl)benzene

HRID 1167706ノート

反応式

HRID 1167706 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9](O)([CH3:11])[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1C=CC=CC=1>[F:8][C:7]1[CH:6]=[CH:5][C:4]([C:9]([CH3:11])=[CH2:10])=[CH:3][C:2]=1[F:1]

参加物

4

反応物 2

HCID 6101p-Toluenesulfonic acidHCID 108210712-(3,4-Difluorophenyl)propan-2-ol

生成物 1

HCID 155252121,2-Difluoro-4-(prop-1-en-2-yl)benzene

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

反応条件

温度
60 °C

実験手順

To a solution of 2-(3,4-difluorophenyl)propan-2-ol (1.0 g, 5.8 mmol) in 40 mL benzene was added 0.1 g of p-toluenesulfonic acid and the solution was heated to 60° C. TLC analysis showed disappearance of the starting material. After cooling, the solution was extracted with EtOAc, washed with saturated NaHCO3, dried over Na2SO4, filtered and the solvent was removed in vacuo. 1,2-difluoro-4-isopropenyl-benzene was obtained as a yellow oil (0.82 g, 92% yield).

後処理

  1. temperatureAfter cooling
  2. extractionthe solution was extracted with EtOAc
  3. washwashed with saturated NaHCO3
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-68d80f066d674cbe92a06bae90410192
出典データセット
uspto-grants-2003_09
特許番号
US06620815B1

反応ノート

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