Diphosgene → 4-Chloro-2,6-difluorophenyl Isocyanate
反応式
[Cl:1][C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.Cl[C:12](OC(Cl)(Cl)Cl)=[O:13]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:8]=[C:7]([F:9])[C:5]([N:6]=[C:12]=[O:13])=[C:4]([F:10])[CH:3]=1参加物
4
実験手順
40 g of 4-chloro-2,6-difluoroaniline were dissolved in 300 ml of absolute toluene. With stirring, 100 ml of trichloromethyl chloroformate were added dropwise at 20° C. The mixture was slowly heated to reflux. After three and half hours, the mixture was concentrated and the resulting isocyanate was used directly for the synthesis of intermediate 3.
後処理
- temperatureThe mixture was slowly heated to reflux
- concentrationAfter three and half hours, the mixture was concentrated
- customthe resulting isocyanate was used directly for the synthesis of intermediate 3
出典と根拠
- ORDレコード
- ord-c72dc09e23a840ff98fb812ba2fd6007
- 出典データセット
- uspto-grants-2003_09
- 特許番号
- US06624119B1
反応ノート
読み込み中…