1,1'-Carbonyldiimidazole → 5-AMINO-6-CHLORO-N-[1-(3-METHOXYPROPYL)-4-PIPERIDINYL]IMIDAZO[1,2-a]PYRIDINE-8-CARBOXAMIDE

HRID 1168247ノート

反応式

HRID 1168247 の反応式
[NH2:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[C:5]([C:11]([OH:13])=O)=[CH:4][C:3]=1[Cl:14].C(N1C=CN=C1)(N1C=CN=C1)=O.[CH3:27][O:28][CH2:29][CH2:30][CH2:31][N:32]1[CH2:37][CH2:36][CH:35]([NH2:38])[CH2:34][CH2:33]1>CN(C)C=O.ClCCl>[NH2:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[C:5]([C:11]([NH:38][CH:35]2[CH2:36][CH2:37][N:32]([CH2:31][CH2:30][CH2:29][O:28][CH3:27])[CH2:33][CH2:34]2)=[O:13])=[CH:4][C:3]=1[Cl:14]

参加物

6

反応物 3

HCID 682631,1'-CarbonyldiimidazoleHCID 120880915-Amino-6-chloroimidazo[1,2-a]pyridine-8-carboxylic acidHCID 120880931-(3-Methoxypropyl)-4-piperidinamine

生成物 1

HCID 120880945-AMINO-6-CHLORO-N-[1-(3-METHOXYPROPYL)-4-PIPERIDINYL]IMIDAZO[1,2-a]PYRIDINE-8-CARBOXAMIDE収率 48%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 6344Dichloromethane溶媒

実験手順

To a suspension of the 5-amino-6-chloroimidazo[1,2-a]pyridine-8-carboxylic acid (EXAMPLE 1, METHOD A, Step 4, 210 mg, 0.99 mmol) in N,N-dimethylformamide (5 mL) was added 1,1′-carbonyldiimidazole (177 mg, 1.09 mmol) and stirred at room temperature for 20 min. To this resulting solution was added 1-(3-methoxypropyl)-4-piperidinamine (A. Karasawa et al., WO 9950264, 188 mg, 1.09 mmol) and the mixture was stirred overnight under nitrogen at room temperature. The mixture was concentrated in vacuo, chromatographed on a column of silica gel eluting with dichloromethane/methanol/25% aqueous ammonia (95:5:0.5) to afford a yellow oil, which was dissolved in dichloromethane (300 mL), washed with water (75 mL×3), brine (75 mL) and dried over magnesium sulfate. After treatment with charcoal, removal of solvent gave a cream solid, which was recrystallized from diethyl ether to afford 175 mg (48%) of the title compound as a solid.

後処理

  1. stirringKarasawa et al., WO 9950264, 188 mg, 1.09 mmol) and the mixture was stirred overnight under nitrogen at room temperature
  2. concentrationThe mixture was concentrated in vacuo
  3. customchromatographed on a column of silica gel eluting with dichloromethane/methanol/25% aqueous ammonia (95:5:0.5)
  4. customto afford a yellow oil, which
  5. washwashed with water (75 mL×3), brine (75 mL)
  6. dry with materialdried over magnesium sulfate
  7. customAfter treatment with charcoal, removal of solvent
  8. customgave a cream solid, which
  9. customwas recrystallized from diethyl ether

出典と根拠

ORDレコード
ord-ddbfa24994564e159e35de49eea8bc47
出典データセット
uspto-grants-2003_09
特許番号
US06624162B2

反応ノート

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