1,1'-Carbonyldiimidazole → HCID 10187735、化合物
反応式
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].[CH2:13]([NH:20][CH2:21][C:22]1[CH:23]=[C:24]([CH2:44][N:45]2[CH2:50][CH2:49][O:48][CH2:47][CH2:46]2)[CH:25]=[C:26]2[C:31]=1[N:30]=[CH:29][C:28]([C:32]([NH:34][CH2:35][C:36]1[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][CH:37]=1)=[O:33])=[C:27]2[OH:43])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CN1C(=O)CCC1>[CH2:13]([N:20]1[CH2:21][C:22]2[C:31]3=[C:26]([C:27](=[O:43])[C:28]([C:32]([NH:34][CH2:35][C:36]4[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][CH:37]=4)=[O:33])=[CH:29][N:30]3[C:1]1=[O:2])[CH:25]=[C:24]([CH2:44][N:45]1[CH2:46][CH2:47][O:48][CH2:49][CH2:50]1)[CH:23]=2)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1参加物
4
実験手順
A solution of 1,1′-carbonyldiimidazole (82 mg) in NMP (2.0 mL) is added over 15 min to a solution of 8-((benzylamino)methyl)-N-(4-chlorobenzyl)-4-hydroxy-6-(4-morpholinylmethyl)-3-quinolinecarboxamide (Preparation 29, 106 mg) in NMP (6 mL). After an additional 15 min, the solvent is removed under reduced pressure and the residual solid is triturated with methanol to afford 93 mg of the title compound. Physical characteristics: M.p. 201-204° C.; 1H NMR (CDCl3) δ2.44, 3.58, 3.70, 4.67, 4.73, 4.87, 7.3-7.45, 7.51, 8.19, 9.90, 10.1; Anal. Found: C, 66.67; H, 5.31; N, 9.99; Cl, 6.35.