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Sodium Hydroxide → 3-Butyl-1-methyl-4-(1-methylindol-3-yl)pyrrole-2,5-dione

HRID 1168659
ノート
印刷プレビュー

反応式

HRID 1168659 の反応式
CC(C)C(N)=O.[OH-].[Na+].CN1C2C(=CC=CC=2)C(C2C(=O)N(C)C(=O)C=2Cl)=C1.[CH3:28][N:29]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[C:31]([C:38]2[C:43](=[O:44])[N:42]([CH3:45])[C:40](=[O:41])[C:39]=2[C:46]2C=C[CH:49]=[CH:48][CH:47]=2)=[CH:30]1.Cl.O>O>[CH3:49][CH2:48][CH2:47][CH2:46][C:39]1[C:40](=[O:41])[N:42]([CH3:45])[C:43](=[O:44])[C:38]=1[C:31]1[C:32]2[C:37](=[CH:36][CH:35]=[CH:34][CH:33]=2)[N:29]([CH3:28])[CH:30]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 5

HCID 14798Sodium HydroxideHCID 68424Isobutyramide2 回HCID 178316153-Chloro-1-methyl-4-(1-methylindol-3-yl)pyrrole-2,5-dioneHCID 178436842-(1-methyl-1H-indol-3-yl)-3-phenyl-N-methylmaleimideHCID 21885828Hydrate;hydrochloride

生成物 1

HCID 1022626083-Butyl-1-methyl-4-(1-methylindol-3-yl)pyrrole-2,5-dione
収率 85.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Into dimethylacetoamide (30 ml) was dispersed sodium hydroxide (content: 60%, 0.88 g, 22 mmol). To this were added IM-3 obtained in Example 1-2 (1.77 g, 10 mmol)/dimethylacetoamide (5 ml). This mixture was stirred for 10 minutes, then, to this was added IM-5 (4.5 g, 11 mmol) obtained as described above, and this mixture was stirred for three hours. To this was added water (10 ml), and this mixture was acidified with 1N water hydrochloride, and the reaction solution was concentrated. The concentrated mixture was refined with silica gel column chromatography to obtain 2.8 g of IM-6.

後処理

  1. customobtained
  2. stirringwas stirred for three hours
  3. concentrationthe reaction solution was concentrated

出典と根拠

ORDレコード
ord-9385340d53934a99add929f6a0125ba7
出典データセット
uspto-grants-2003_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06627099B2

反応ノート

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