3-Hydroxy-2-hydroxymethyl-6-methylpyridine → 3-Hydroxy-6-methylpyridine-2-carbaldehyde

HRID 11693

反応式

HRID 11693 の反応式
[OH:1][CH2:2][C:3]1[C:8]([OH:9])=[CH:7][CH:6]=[C:5]([CH3:10])[N:4]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[OH:9][C:8]1[C:3]([CH:2]=[O:1])=[N:4][C:5]([CH3:10])=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 1351283-Hydroxy-2-hydroxymethyl-6-methylpyridine

生成物 1

HCID 124219863-Hydroxy-6-methylpyridine-2-carbaldehyde収率 7.1%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2-hydroxymethyl-6-methyl-pyridin-3-ol (1.0 g, 7.19 mmol) in methylene chloride (30 mL) at ambient temperature was added manganese dioxide (12.5 g, 143 mmol). The reactions was stirred for 48 hours, then filtered through celite and concentrated to give the title compound (0.070 g).

後処理

  1. filtrationfiltered through celite and
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-02ad876e63fb458292e9317dfd5c8fb7
出典データセット
uspto-grants-2006_08
特許番号
US07098212B2

関連ノート

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