Methyl iodide → HCID 22990064、化合物

HRID 1169435ノート

反応式

HRID 1169435 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:28]=[CH:29][CH:30]=1)[C:12]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)=[CH:17][CH:16]=1)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[I:32].[C:33](OCC)(=O)C>CN(C=O)C>[I-:32].[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:28]=[CH:29][CH:30]=1)[C:12]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N+:22]2([CH3:33])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]2)=[CH:17][CH:16]=1)=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 29671333-(Phenylmethoxy)-N-[4-(1-piperidinylmethyl)phenyl]benzamide

生成物 1

HCID 22990064HCID 22990064、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To 3-benzyloxy -4′-(piperidinomethyl)benzanilide (560 mg) dissolved in DMF (3 ml) was added methyl iodide (261 μl), and the resulting mixture was stirred at room temperature for 14 hours. Ethyl acetate (100 ml) was added to this reaction mixture, and the resulting precipitate was collected by filtration to obtain 1-[4-(3-benzyloxybenzoylamino)benzyl]-1-methylpiperidinium iodide (compound 87) (724 mg) as colorless crystals.

後処理

  1. filtrationthe resulting precipitate was collected by filtration

出典と根拠

ORDレコード
ord-cebaaf440f524928b6888f9b4a0003b1
出典データセット
uspto-grants-2003_09
特許番号
US06627651B1

反応ノート

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