Methanol → 3,4-Diethoxybenzyl alcohol

HRID 1169503ノート

反応式

HRID 1169503 の反応式
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH3:14])[CH:7]=[O:8])[CH3:2].CO.[BH4-].[Na+]>O>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH3:14])[CH2:7][OH:8])[CH3:2]

参加物

5

反応物 3

HCID 887MethanolHCID 748473,4-DiethoxybenzaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 8540533,4-Diethoxybenzyl alcohol収率 98.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

To a mixture of 3,4-diethoxybenzaldehyde (6.68 g) and methanol (100 ml) was added sodium borohydride (1.30 g) at 0° C. The resulting mixture was stirred at 0° C. for 45 minutes. The reaction mixture was mixed with water and was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated solution of sodium chloride and was dried with anhydrous magnesium sulfate. The resulting organic layer was evaporated under reduced pressure to remove the solvent to obtain 3,4-diethoxybenzyl alcohol (6.64 g) as a yellow oil.

後処理

  1. extractionwas extracted with ethyl acetate
  2. washThe organic layer was washed with an aqueous saturated solution of sodium chloride
  3. dry with materialwas dried with anhydrous magnesium sulfate
  4. customThe resulting organic layer was evaporated under reduced pressure
  5. customto remove the solvent

出典と根拠

ORDレコード
ord-5f8fa155e3e64a7bb4d8f6ea9166fbdd
出典データセット
uspto-grants-2003_09
特許番号
US06627651B1

反応ノート

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