tert-Butyl acrylate → tert-butyl N-[3-(4-hydroxyphenyl)propyl]-beta-alaninate

HRID 1169630ノート

反応式

HRID 1169630 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[C:12]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])(=[O:15])[CH:13]=[CH2:14]>CO>[OH:11][C:8]1[CH:7]=[CH:6][C:5]([CH2:4][CH2:3][CH2:2][NH:1][CH2:14][CH2:13][C:12]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 15458tert-Butyl acrylateHCID 4574248HCID 4574248、化合物

生成物 1

HCID 23121488tert-butyl N-[3-(4-hydroxyphenyl)propyl]-beta-alaninate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a methanol solution (25 mL) of 4-(3-aminopropyl)phenol (1.83 g), tert-butyl acrylate (1.7 mL) was added dropwise thereto at room temperature, followed by stirring at room temperature overnight. The reaction mixture was concentrated. The residue was purified by silica gel column chromatography (ethyl acetate→ethyl acetate:methanol=3:1) to give the title compound (1.55 g) having the following physical properties. TLC: Rf 0.24 (ethyl acetate:methanol 5:1);

後処理

  1. customat room temperature
  2. concentrationThe reaction mixture was concentrated
  3. customThe residue was purified by silica gel column chromatography (ethyl acetate→ethyl acetate:methanol=3:1)

出典と根拠

ORDレコード
ord-0fab8896541841cc802419e13b1774b8
出典データセット
uspto-grants-2010_11
特許番号
US07825109B2

反応ノート

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