(RS)-S-(4-nitrophenyl)-N-(2-methoxy-acetyl)-S-methylsulfoximide → (RS)-S-(4-aminophenyl)-N-(2-methoxy-acetyl)-S-methylsulphoximide

HRID 1169721ノート

反応式

HRID 1169721 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([CH3:18])(=[N:12][C:13](=[O:17])[CH2:14][O:15][CH3:16])=[O:11])=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([S:10]([CH3:18])(=[N:12][C:13](=[O:17])[CH2:14][O:15][CH3:16])=[O:11])=[CH:6][CH:5]=1

参加物

4

反応物 1

HCID 59550858(RS)-S-(4-nitrophenyl)-N-(2-methoxy-acetyl)-S-methylsulfoximide

生成物 1

HCID 59550852(RS)-S-(4-aminophenyl)-N-(2-methoxy-acetyl)-S-methylsulphoximide収率 53%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

反応条件

温度
24 °C

実験手順

107 mg (0.39 mmol) (RS)—S-(4-nitrophenyl)-N-(2-methoxy-acetyl)-S-methylsulphoximide is dissolved in 13.6 ml ethanol and treated with 40 mg palladium on activated charcoal (10% Pd). The mixture is stirred under hydrogen at normal pressure for 60 minutes at 24° C. The catalyst is filtered off and the solution concentrated. After chromatographic purification (silica gel, hexane/ethyl acetate (0-50% ethyl acetate)), 50 mg (53%) of the desired product is obtained.

後処理

  1. filtrationThe catalyst is filtered off
  2. concentrationthe solution concentrated
  3. customAfter chromatographic purification (silica gel, hexane/ethyl acetate (0-50% ethyl acetate))

出典と根拠

ORDレコード
ord-60f05c1c629647e28aa98ae310dfe87f
出典データセット
uspto-grants-2010_11
特許番号
US07825128B2

反応ノート

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