Hydrochloric Acid → 1-Phenyl-2-pyridin-2-ylethane-1,2-dione 2-oxime

HRID 1170391ノート

反応式

HRID 1170391 の反応式
[N:1]([O-:3])=O.[Na+].[C:5]1([C:11](=[O:19])[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.Cl.C(=O)([O-])[O-].[Na+].[Na+]>O>[C:5]1([C:11](=[O:19])[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)=[N:1][OH:3])[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 741791-Phenyl-2-(2-pyridinyl)ethanoneHCID 23668193Sodium Nitrite

生成物 1

HCID 1364068481-Phenyl-2-pyridin-2-ylethane-1,2-dione 2-oxime

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A solution of 8.75 g (127 mmol) of sodium nitrite in water was added dropwise to a solution of 25 g (127 mmol) of 1-phenyl-2-pyridin-2-ylethanone in 250 ml of water/conc. hydrochloric acid (8:1) at room temperature. After 2 h, the solution was neutralized with sodium carbonate. The product crystallized out overnight to result in 25.3 g of 1-phenyl-2-pyridin-2-ylethane-1,2-dione 2-oxime.

後処理

  1. customat room temperature
  2. customThe product crystallized out overnight
  3. customto result in 25.3 g of 1-phenyl-2-pyridin-2-ylethane-1,2-dione 2-oxime

出典と根拠

ORDレコード
ord-8705773e83c54b16b80cb096800fd60a
出典データセット
uspto-grants-2010_11
特許番号
US07825264B2

反応ノート

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