Water → 1-(2-(1H-Imidazol-1-YL)-6-methylpyrimidin-4-YL)ethanone
反応式
CON(C)[C:4]([C:6]1[CH:11]=[C:10]([CH3:12])[N:9]=[C:8]([N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)[N:7]=1)=[O:5].[CH3:19][Mg+].[Br-].O>C1COCC1>[N:13]1([C:8]2[N:7]=[C:6]([C:4](=[O:5])[CH3:19])[CH:11]=[C:10]([CH3:12])[N:9]=2)[CH:17]=[CH:16][N:15]=[CH:14]1参加物
5
実験手順
To a solution of 2-imidazol-1-yl-6-methyl-pyrimidine-4-carboxylic acid methoxy-methyl-amide (162 mg, 0.800 mmol) in THF (10 mL) at 0° C. was added MeMgBr (0.8 mL, 3M in Et2O, 2.40 mmol). The solution was warmed to rt and stirred for 20 min. Water was added and the mixture was extracted with ethyl acetate, washed with brine and dried over Na2SO4. Evaporation of the solvent gave 143 mg (88%) of 1-(2-imidazol-1-yl-6-methyl-pyrimidin-4-yl)-ethanone as a yellow solid. [M+H]+ 203.17.
後処理
- extractionthe mixture was extracted with ethyl acetate
- washwashed with brine
- dry with materialdried over Na2SO4
- customEvaporation of the solvent
出典と根拠
- ORDレコード
- ord-06711d698ea64476962752ae4ca9ecae
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07825256B2
反応ノート
読み込み中…