Sodium Iodide → HCID 18400042、化合物

HRID 1170692ノート

反応式

HRID 1170692 の反応式
[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([CH2:7][O:8][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16]Cl)=[O:14])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[I-:22].[Na+]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([CH2:7][O:8][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][I:22])=[O:14])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 22035697HCID 22035697、化合物

生成物 1

HCID 18400042HCID 18400042、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of chloromethyl 4-(4-methoxybenzyloxy)benzoate (0.77 g, 2.5 mmole) in 15 ml dry acetone was added sodium iodide (1.87 g, 12.5 mmole) and the mixture was stirred overnight at room temperature. The mixture was evaporated under reduced pressure and extracted with ethyl acetate/water. The organic phase was washed with a 5% sodium thiosulfate solution, dried with sodium sulfate and evaporated under reduced pressure. Yield 0.86 g=86%

後処理

  1. customThe mixture was evaporated under reduced pressure
  2. extractionextracted with ethyl acetate/water
  3. washThe organic phase was washed with a 5% sodium thiosulfate solution
  4. dry with materialdried with sodium sulfate
  5. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-0e83f2d75aaa4a5cbd831091812e3581
出典データセット
uspto-grants-2010_11
特許番号
US07825238B2

反応ノート

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