Morpholine → (2-Amino-5-bromophenyl)(morpholino)methanone
反応式
[Br:1][C:2]1[CH:13]=[C:6]2[C:7]([O:9]C(=O)[NH:11][C:5]2=[CH:4][CH:3]=1)=O.[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>C1COCC1>[NH2:11][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:13][C:6]=1[C:7]([N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)=[O:9]参加物
4
実験手順
Into an 8 mL screw cap vial were added 5-bromoisatoic anhydride (0.200 g, 0.826 mmol), anhydrous THF (5 mL), and morpholine (101 mg, 1.16 mmol). The vial was sealed and placed in a heat block at 60° C. for 1.5 h after which it was concentrated under vacuum. The crude product was triturated with Et2O/hexanes to afford 111 mg (94%) of (2-Amino-5-bromo-phenyl)-morpholin-4-yl-methanone as a tan solid. m/z 285/287 [MH+].
後処理
- customInto an 8 mL screw cap vial
- customThe vial was sealed
- concentrationafter which it was concentrated under vacuum
- customThe crude product was triturated with Et2O/hexanes
出典と根拠
- ORDレコード
- ord-817d554650e94d0d89405e7464208b42
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07829558B2
反応ノート
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