Hydrochloric Acid → (S)-mandelic acid

HRID 1171616

反応式

HRID 1171616 の反応式
[C:1]([O-:11])(=[O:10])[C@@H:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3].Cl>O>[C:1]([OH:11])(=[O:10])[C@H:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 5460269(R)-Mandelate2 回

生成物 1

HCID 439616(S)-mandelic acid収率 57%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
1 °C

実験手順

The L-mandelate (S,R,R salt 2, 274 g, 1.03 mol) was dissolved in water (400 ml) and brought to pH 1.5 by adding concentrated hydrochloric acid. The mixture was cooled to 1° C. and seeded by adding a few crystals of S-mandelic acid. The mixture was stirred at 0° C. for a further 2 hours and the precipitated crystal slurry was filtered with suction. The filter residue was washed with ice-water (100 ml) and dried at 50° C. under reduced pressure. 86 g (57%) of L-mandelic acid were obtained, which were optically pure according to analysis.

後処理

  1. filtrationthe precipitated crystal slurry was filtered with suction
  2. washThe filter residue was washed with ice-water (100 ml)
  3. customdried at 50° C. under reduced pressure

出典と根拠

ORDレコード
ord-a33c80d9c77049f1ab953f801eddba31
出典データセット
uspto-grants-2010_11
特許番号
US07829702B2

関連ノート

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