反応式
C[Si]([CH2:5][C:6]#[N:7])(C)C.C([N-]C(C)C)(C)C.[Li+].[C:16]([O:20][C:21]([N:23]1[CH2:28][CH2:27][CH:26]([O:29][Si:30]([C:33]([CH3:36])([CH3:35])[CH3:34])([CH3:32])[CH3:31])[C:25](=O)[CH2:24]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]>O1CCCC1>[C:16]([O:20][C:21]([N:23]1[CH2:28][CH2:27][CH:26]([O:29][Si:30]([C:33]([CH3:36])([CH3:34])[CH3:35])([CH3:31])[CH3:32])/[C:25](=[CH:5]\[C:6]#[N:7])/[CH2:24]1)=[O:22])([CH3:18])([CH3:17])[CH3:19]参加物
5
反応物 3
生成物 1
試薬・触媒・溶媒 1
反応条件
- 温度
- -78 °C
実験手順
To a solution of trimethylsilylacetonitrile (1.3 ml) in tetrahydrofuran (THF) (30 ml) was added at −78° C. lithium diisopropylamide (2.0 M in hexane, 4.7 ml). The resulting mixture was stirred at −78° C. for 0.5 hours, and then a solution of 1-(t-butoxycarbonyl)-4-(t-butyldimethylsilyloxy)piperidin-3-one (3 g) in THF (10 ml) was added at the same temperature. The resulting mixture was stirred for one hour while the temperature was raised to room temperature. The mixture was concentrated in vacuo, and the residue was purified by chromatography on silica gel using a mixture of hexane and ethyl acetate (9:1) as the eluent to afford the title compound (880 mg, yield: 27%) as the less polar isomer as a yellow oil.
後処理
- stirringThe resulting mixture was stirred for one hour while the temperature
- temperaturewas raised to room temperature
- concentrationThe mixture was concentrated in vacuo
- customthe residue was purified by chromatography on silica gel using
- additiona mixture of hexane and ethyl acetate (9:1) as the eluent
出典と根拠
- ORDレコード
- ord-1dc922227a074c8992803e6e194ea0f5
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07829580B2
関連ノート
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