関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Succinic Acid | HCID 1110 | — |
| 反応物 | Solifenacin | HCID 154059 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Solifenacin Succinate | HCID 216457 | — |
反応手順
The thus obtained solifenacin was mixed with 12 ml of EtOH, 28 ml of EtOAc and 2.74 g of succinic acid, heated, cooled to 30° C. and then again heated to 50° C. This was kept at 50° C. for 2 hours and then cooled to 0° C. spending 5 hours, and the precipitated crystals were collected by filtration, washed twice with 8 ml of EtOAc and then dried under a reduced pressure to obtain 9.013 g of solifenacin succinate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07829715B2 |
|---|
| 出典データセット | uspto-grants-2010_11 |
|---|
| ORD ID | ord-b008daffcd744614946eb1f37250dec3 |
|---|
| 出典メモ | uspto-grants-2010_11 |
|---|
