反应详情

温度

30 °C

The thus obtained solifenacin was mixed with 12 ml of EtOH, 28 ml of EtOAc and 2.74 g of succinic acid, heated, cooled to 30° C. and then again heated to 50° C. This was kept at 50° C. for 2 hours and then cooled to 0° C. spending 5 hours, and the precipitated crystals were collected by filtration, washed twice with 8 ml of EtOAc and then dried under a reduced pressure to obtain 9.013 g of solifenacin succinate.

1. temperatureheated
2. temperatureagain heated to 50° C
3. temperaturecooled to 0° C.
4. waitspending 5 hours
5. filtrationthe precipitated crystals were collected by filtration
6. washwashed twice with 8 ml of EtOAc
7. customdried under a reduced pressure