Hydrogen Bromide → (S)-(+)-2-Amino-4-bromobutyric Acid Hydrobromide
反応式
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][O:5][C:4]1=[O:8].[BrH:9]>CC(O)=O>[BrH:9].[NH2:2][C@@H:3]([CH2:7][CH2:6][Br:9])[C:4]([OH:5])=[O:8]参加物
4
実験手順
(S)-3-aminodihydrofuran-2(3H)-one hydrochloride (10.30 g, 74.87 mmol) in 58 mL of 30% w/w HBr in HOAc was stirred at 65° C. for 30 hrs. The solvent was removed under reduced pressure and the resulted solid was suspended in MTBE (200 mL) and stirred for 30 min. The solid was collected by filtration and washed with MTBE (200 mL) and dried to give (S)-2-amino-4-bromobutanoic acid hydrobromide as white solid (19.33 g, 98%). 1H NMR (400 MHz, d6-DMSO) δ8.37 (s, 3H), 4.01 (m, 1H), 3.65 (m, 2H), 2.33 (m, 2H).
後処理
- customThe solvent was removed under reduced pressure
- filtrationThe solid was collected by filtration
- washwashed with MTBE (200 mL)
- customdried
出典と根拠
- ORDレコード
- ord-1a37dae5de404242af16ed2417d68b3e
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07829665B2
反応ノート
読み込み中…