t-Butyl 5-(6-hydroxymethylpyridin-2-yl)pent-4-ynoate → t-Butyl 5-(6-hydroxymethylpyridin-2-yl)pentanoate

HRID 1172259ノート

反応式

HRID 1172259 の反応式
[OH:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]#[C:10][CH2:11][CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH:6]=[CH:5][CH:4]=1>[Pt](=O)=O.CCO>[OH:1][CH2:2][C:3]1[N:8]=[C:7]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 1

HCID 58105203t-Butyl 5-(6-hydroxymethylpyridin-2-yl)pent-4-ynoate

生成物 1

HCID 58105232t-Butyl 5-(6-hydroxymethylpyridin-2-yl)pentanoate収率 99.2%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

To a 200 mL round-bottom flask, 2.76 g of t-butyl 5-(6-hydroxymethylpyridin-2-yl)pent-4-ynoate, 50 mg of platinum dioxide and 25 mL of EtOH were added, the mixture was stirred under hydrogen atmosphere at room temperature for 8 hours. The insoluble material was removed off, and then the filtrate was concentrated to give 2.78 g of t-butyl 5-(6-hydroxymethylpyridin-2-yl)pentanoate as a yellow oil.

後処理

  1. customThe insoluble material was removed off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-b3557cc3c3604bea910fc2c8574264b1
出典データセット
uspto-grants-2010_11
特許番号
US07834002B2

反応ノート

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