TBAF tetrahydrofuran → (6-(Thiazol-2-ylamino)pyridin-2-yl)methanol

HRID 1172412ノート

反応式

HRID 1172412 の反応式
[Si]([O:8][CH2:9][C:10]1[N:15]=[C:14]([NH:16][C:17]2[S:18][CH:19]=[CH:20][N:21]=2)[CH:13]=[CH:12][CH:11]=1)(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC.O1CCCC1>O1CCCC1.C(OCC)(=O)C>[S:18]1[CH:19]=[CH:20][N:21]=[C:17]1[NH:16][C:14]1[N:15]=[C:10]([CH2:9][OH:8])[CH:11]=[CH:12][CH:13]=1

参加物

5

反応物 2

HCID 11078149TBAF tetrahydrofuranHCID 57562580HCID 57562580、化合物

生成物 1

HCID 57562655(6-(Thiazol-2-ylamino)pyridin-2-yl)methanol

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

6.48 g of 6-(((tert-butyl(dimethyl)silyl)oxy)methyl)-N-thiazol-2-ylpyridin-2-amine was dissolved in 100 ml of tetrahydrofuran. Under cooling with ice, a tetrabutylammonium fluoride-tetrahydrofuran solution (1.0 M, 20.2 ml) was added followed by stirring at room temperature for 1 hour. The reaction solution was diluted with ethyl acetate and then washed with phosphate buffer (pH 6.8). The organic layer was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated to give the title compound.

後処理

  1. temperatureUnder cooling with ice
  2. washwashed with phosphate buffer (pH 6.8)
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-7581c32cd57e40a8bfdb717316fe3613
出典データセット
uspto-grants-2010_11
特許番号
US07834018B2

反応ノート

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