Sodium Carbonate → cis-(2-Pyrimidin-2-yl-octahydro-pyrido[1,2-a]pyrazin-7-yl)-methanol

HRID 1172560ノート

反応式

HRID 1172560 の反応式
[CH2:1]1[NH:6][CH2:5][CH2:4][N:3]2[CH2:7][C@H:8]([CH2:11][OH:12])[CH2:9][CH2:10][C@@H:2]12.Cl[C:14]1[N:19]=[CH:18][CH:17]=[CH:16][N:15]=1.C([O-])([O-])=O.[Na+].[Na+]>O>[N:15]1[CH:16]=[CH:17][CH:18]=[N:19][C:14]=1[N:6]1[CH2:5][CH2:4][N:3]2[CH2:7][C@H:8]([CH2:11][OH:12])[CH2:9][CH2:10][C@H:2]2[CH2:1]1

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 744042-ChloropyrimidineHCID 10035034((7R,9AS)-Octahydro-1H-pyrido[1,2-A]pyrazin-7-YL)methanol

生成物 1

HCID 14995231cis-(2-Pyrimidin-2-yl-octahydro-pyrido[1,2-a]pyrazin-7-yl)-methanol

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
95 °C

実験手順

Cis-(octahydro-pyrido[1,2-a]pyrazin-7-yl)-methanol (1 eq), 2-chloro-pyrimidine (1 eq.), and Na2CO3 (1 eq.) were dissolved in water. The mixture was stirred at around 95° C. for overnight. The solution was cooled to room temperature and extracted with methylene chloride. The combined organic layers was washed with brine, dried over Na2SO4, filtered and concentrated to give cis-(2-pyrimidin-2-yl-octahydro-pyrido[1,2-a]pyrazin-7-yl)-methanol as a white solid. This material was used in the next step without further purification.

後処理

  1. temperatureThe solution was cooled to room temperature
  2. extractionextracted with methylene chloride
  3. washThe combined organic layers was washed with brine
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-3f01ef0aa3e34a8da279058e905b7167
出典データセット
uspto-grants-2010_11
特許番号
US07834014B2

反応ノート

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