Methyl 4,5-difluoro-2-nitrobenzoate → Methyl 2-amino-4,5-difluorobenzoate

HRID 1172575ノート

反応式

HRID 1172575 の反応式
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([N+:13]([O-])=O)[CH:3]=1>CCOC(C)=O.[Pd]>[NH2:13][C:4]1[CH:3]=[C:2]([F:1])[C:11]([F:12])=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7]

参加物

4

反応物 1

HCID 21928432Methyl 4,5-difluoro-2-nitrobenzoate

生成物 1

HCID 18472001Methyl 2-amino-4,5-difluorobenzoate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of methyl 4,5-difluoro-2-nitrobenzoate 1b (23.0 g, 106 mmol) in EtOAc (200 mL), was added 10% Pd/C (wet, 50% water, 6.0 g), and the mixture was shaken on a Parr hydrogenator at 50 PSI for 3 hr. The reaction mixture was then filtered through a celite pad and the filtrate was concentrated by rotary evaporation to yield methyl 2-amino-4,5-difluorobenzoate 1c as a colorless solid, 19.0 g (96%).

後処理

  1. filtrationThe reaction mixture was then filtered through a celite pad
  2. concentrationthe filtrate was concentrated by rotary evaporation

出典と根拠

ORDレコード
ord-45385cb6efd6409489cbe974d0784412
出典データセット
uspto-grants-2010_11
特許番号
US07834023B2

反応ノート

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