HCID 59556306、化合物 → HCID 59556317、化合物

HRID 1172665ノート

反応式

HRID 1172665 の反応式
[F:1][C:2]([F:23])([CH:21]=[CH2:22])[CH:3]([C:5]1[S:9][C:8]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[N:7][C:6]=1[CH3:20])[OH:4]>C(OCC)(=O)C.[Pd]>[F:23][C:2]([F:1])([CH2:21][CH3:22])[CH:3]([C:5]1[S:9][C:8]([C:10]2[CH:11]=[CH:12][C:13]([C:16]([F:17])([F:18])[F:19])=[CH:14][CH:15]=2)=[N:7][C:6]=1[CH3:20])[OH:4]

参加物

4

反応物 1

HCID 59556306HCID 59556306、化合物

生成物 1

HCID 59556317HCID 59556317、化合物収率 96.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

740 mg 2,2-Difluoro-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-but-3-en-1-ol were dissolved in 50 ml ethyl acetate. 50 mg palladium (5% on charcoal) were added and the reaction mixture stirred at room temperature under a hydrogen atmosphere. After three hours the catalyst was filtered off and the filtrate evaporated in vacuo to obtain 720 mg 2,2-Difluoro-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-butan-1-ol as a white solid.

後処理

  1. filtrationAfter three hours the catalyst was filtered off
  2. customthe filtrate evaporated in vacuo

出典と根拠

ORDレコード
ord-26ff59966e054b88a6bc71f0679c9e2e
出典データセット
uspto-grants-2010_11
特許番号
US07834030B2

反応ノート

読み込み中…