反応式
[CH3:1][C:2]1[N:3]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[S:5][C:6]=1[CH:7]([OH:10])[CH2:8][CH3:9].[H-].[Na+].[Br:23][C:24]1[CH:31]=[C:30](F)[CH:29]=[CH:28][C:25]=1[C:26]#[N:27].O>CN(C)C=O>[Br:23][C:24]1[CH:31]=[C:30]([O:10][CH:7]([C:6]2[S:5][C:4]([C:11]3[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:13][CH:12]=3)=[N:3][C:2]=2[CH3:1])[CH2:8][CH3:9])[CH:29]=[CH:28][C:25]=1[C:26]#[N:27]参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
500 mg 1-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-propan-1-ol were dissolved in 5 ml dimethylformamide. 108 mg sodium hydride were added and the mixture stirred at room temperature. After thirty minutes commercially available 2-bromo-4-fluorobenzonitrile were added and the reaction mixture stirred at room temperature for one hour. Then 5 ml water were added and the mixture extracted three times with portions of 30 ml ethyl acetate. The combined organic layers were dried over MgSO4 and the solvent removed in vacuo. The residue was purified by reversed phase HPLC to obtain 375 mg 2-Bromo-4-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-propoxy}-benzonitrile as an oil.
後処理
- stirringthe reaction mixture stirred at room temperature for one hour
- extractionthe mixture extracted three times with portions of 30 ml ethyl acetate
- dry with materialThe combined organic layers were dried over MgSO4
- customthe solvent removed in vacuo
- customThe residue was purified by reversed phase HPLC
出典と根拠
- ORDレコード
- ord-939762503f8349c09e26624e93e55592
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07834030B2
関連ノート
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