Chlorosuccinimide → 5-[(6,7-Dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzonitrile

HRID 1172794ノート

反応式

HRID 1172794 の反応式
FC(F)(F)C([O-])=O.[Cl:8][C:9]1[CH:10]=[C:11]2[C:16](=[O:17])[NH:15][CH:14]=[C:13]([CH2:18][C:19]3[CH:20]=[CH:21][C:22]([F:34])=[C:23]([CH:33]=3)[C:24]([N:26]3CCC[NH2+]CC3)=O)[N:12]2[CH:35]=1.[Cl:36]C1C=C2C(=O)NC=C(CC3C=CC(F)=C(C=3)C#N)N2C=1.ClN1C(=O)CCC1=O>C1COCC1>[Cl:36][C:35]1[N:12]2[C:13]([CH2:18][C:19]3[CH:20]=[CH:21][C:22]([F:34])=[C:23]([CH:33]=3)[C:24]#[N:26])=[CH:14][NH:15][C:16](=[O:17])[C:11]2=[CH:10][C:9]=1[Cl:8]

参加物

5

反応物 3

HCID 31398ChlorosuccinimideHCID 686864115-[(7-Chloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzonitrileHCID 686892094-{5-[(7-Chloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzoyl}-1,4-diazepan-1-ium trifluoroacetate

生成物 1

HCID 252240505-[(6,7-Dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzonitrile

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of Example 6, F5 (1 eq) and N-chlorosuccinimide (2 eq) in THF was stirred at RT. The solvent was removed under reduced pressure and the resulting crude was used as such in the next step without purification. MS (ES) C15H8Cl2FN3O requires: 335, found: 336 (M+H)+.

後処理

  1. customThe solvent was removed under reduced pressure
  2. customwithout purification

出典と根拠

ORDレコード
ord-d2f68aff7fb94656ae179ce69d097b17
出典データセット
uspto-grants-2010_11
特許番号
US07834015B2

反応ノート

読み込み中…