Trifluoroacetic acid → 5-(Methoxycarbonyl)benzo[b]thiophene-2-carboxylic acid

HRID 1172848ノート

反応式

HRID 1172848 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:20]=[CH:19][C:8]2[S:9][C:10]([C:12]([O:14]C(C)(C)C)=[O:13])=[CH:11][C:7]=2[CH:6]=1)=[O:4].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[CH:20]=[CH:19][C:8]2[S:9][C:10]([C:12]([OH:14])=[O:13])=[CH:11][C:7]=2[CH:6]=1)=[O:4]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 59556407Benzo[b]thiophene-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester

生成物 1

HCID 595564095-(Methoxycarbonyl)benzo[b]thiophene-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of benzo[b]thiophene-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester (3.018 g, 10.32 mmol) and TFA (20 mL) in CH2Cl2 (50 mL) was allowed to stir at rt for four days. The reaction mixture was concentrated and dried under high vacuum to give benzo[b]thiophene-2,5-dicarboxylic acid 5-methyl ester as a pale solid. MS (EI): cal'd 237.0 (MH+), exp 237.1 (MH+).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customdried under high vacuum

出典と根拠

ORDレコード
ord-3f805adbaac54592967313b717127e28
出典データセット
uspto-grants-2010_11
特許番号
US07834034B2

反応ノート

読み込み中…