Hydrochloric Acid → 6-(Carbamoyl-fluoro-methyl)benzo[b]thiophene-2-carboxylic acid
反応式
C([O:3][C:4]([C:6]1[S:10][C:9]2[CH:11]=[C:12]([CH:15]([C:17](=[O:19])[NH2:18])[F:16])[CH:13]=[CH:14][C:8]=2[CH:7]=1)=[O:5])C.[Li+].[OH-].Cl>CO.C1COCC1>[C:17]([CH:15]([F:16])[C:12]1[CH:13]=[CH:14][C:8]2[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[S:10][C:9]=2[CH:11]=1)(=[O:19])[NH2:18]参加物
5
実験手順
To a solution of 6-(carbamoyl-fluoro-methyl)-benzo[b]thiophene-2-carboxylic acid ethyl ester (295 mg, 1.05 mmol) in MeOH/THF (1.5/6 mL) was added 1M LiOH (1.16 mL). The resultant solution was stirred overnight and 1N HCl was added dropwise to acidify (˜2 mL). The solvent was removed in vacuo and the solid was used without further purification. cal'd 254 (MH+), exp 254 (MH+).
後処理
- customThe solvent was removed in vacuo
- customthe solid was used without further purification
出典と根拠
- ORDレコード
- ord-39a5a77b3c6741fb9f3060019c48440c
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07834034B2
反応ノート
読み込み中…