反応式
N.Br[C:3]1[N:4]=[CH:5][CH:6]=[C:7]2[CH:11]=[CH:10][NH:9][C:8]=12.BrC1C([N+]([O-])=O)=CC=C[N:14]=1>[Cu]>[NH2:14][C:3]1[N:4]=[CH:5][CH:6]=[C:7]2[CH:11]=[CH:10][NH:9][C:8]=12参加物
5
反応条件
- 温度
- 120 °C
実験手順
To 84 ml of aqueous concentrated ammonia were added 600 mg (3.05 mmol) of 7-bromo-1H-pyrrolo[2,3-c]pyridine synthesized from 2-bromo-3-nitropyridine in the same manner as in Production Example 1a, 194 mg of a copper powder and 603 mg of cuprous chloride. The mixture was heated in a sealed tube at 120° C. for 15 hours and then treated, to give 170 mg of 7-amino-1H-pyrrolo[2,3-c]pyridine. The resulting product was reacted and treated in the same manner as in Examples 1a and 2a, to give 57 mg of the title compound.
後処理
- additiontreated
出典と根拠
- ORDレコード
- ord-1984b068d707462f827e7c0a08a19cc2
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07834049B2
関連ノート
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