Water → N-(3-Nitrophenethyl)acetamide

HRID 1173125ノート

反応式

HRID 1173125 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[CH2:7][CH2:8][NH2:9])([O-:3])=[O:2].[C:13](Cl)(=[O:15])[CH3:14].O>N1C=CC=CC=1>[C:13]([NH:9][CH2:8][CH2:7][C:6]1[CH:10]=[CH:11][CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)(=[O:15])[CH3:14]

参加物

5

反応物 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 129500662-(3-Nitrophenyl)ethan-1-amine

生成物 1

HCID 22674066N-(3-Nitrophenethyl)acetamide収率 91%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

3-Nitrophenethylamine (5.559 g, Production Example 25b) was dissolved in pyridine (33 ml), and acetyl chloride (2.5 ml) was added dropwise thereinto under ice-cooling. After stirring at room temperature for 0.5 hr, the mixture was ice-cooled again. Water was added thereto, and the mixture was extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, to give the title compound (6.323 g, 91%) as a yellow oil.

後処理

  1. temperatureunder ice-cooling
  2. temperaturecooled again
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe extract was washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-7260cf56fccf496ba7bdd8d0ba480c03
出典データセット
uspto-grants-2010_11
特許番号
US07834049B2

反応ノート

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