Sodium borohydride → 2-(3-Nitrophenyl)propan-1-ol
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]([CH3:13])[CH:11]=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[BH4-].[Na+]>C(O)C.[Cl-].[Na+].O>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]([CH3:13])[CH2:11][OH:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]参加物
5
実験手順
2-(3-Nitrophenyl)propanal (7.531 g) was dissolved in ethanol (100 ml), to which was then added sodium borohydride (1.9 g) under ice-cooling, followed by stirring at room temperature for one hour. Brine was added thereto, followed by extracting with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. A residue obtained by evaporating the solvent was purified by silica gel column, to give the title compound (6.275 g, 57.19% in 3 steps) as a brown oil.
後処理
- extractionby extracting with ethyl acetate
- washThe extract was washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- customA residue obtained
- customby evaporating the solvent
- customwas purified by silica gel column
出典と根拠
- ORDレコード
- ord-ad3602dcf0034d8c92c6970e9efe97e1
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07834049B2
反応ノート
読み込み中…