Hydrochloric Acid → 4-Hydroxy-4-(3-methyl-isothiazol-5-yl)-cyclohexanone

HRID 1173294ノート

反応式

HRID 1173294 の反応式
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2([OH:17])[CH2:16][CH2:15][C:10]3(OCC[O:11]3)[CH2:9][CH2:8]2)[S:4][N:3]=1.Cl.C(=O)([O-])[O-].[K+].[K+].CCOC(C)=O>O1CCCC1.O>[OH:17][C:7]1([C:5]2[S:4][N:3]=[C:2]([CH3:1])[CH:6]=2)[CH2:16][CH2:15][C:10](=[O:11])[CH2:9][CH2:8]1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 59556170HCID 59556170、化合物

生成物 1

HCID 595561244-Hydroxy-4-(3-methyl-isothiazol-5-yl)-cyclohexanone

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

8-(3-Methyl-isothiazol-5-yl)-1,4-dioxa-spiro[4.5]decan-8-ol (0.76 g, 0.0030 mol) was dissolved in tetrahydrofuran (10 mL), and a solution of 3.0 M of hydrogen chloride in water (5.0 mL) was added. The mixture was stirred overnight. Solid potassium carbonate was added to neutralize the acid and EtOAc was added to extract the product. The extract was dried and concentrated to give a crude product which was used directly for next step.

後処理

  1. additionwas added
  2. extractionto extract the product
  3. customThe extract was dried
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-16f2977455604dddb919d0715283b4a2
出典データセット
uspto-grants-2010_11
特許番号
US07834021B2

反応ノート

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